Cocaine‐ and amphetamine‐regulated transcript is increased in Huntington disease
Identifieur interne : 002F52 ( Main/Exploration ); précédent : 002F51; suivant : 002F53Cocaine‐ and amphetamine‐regulated transcript is increased in Huntington disease
Auteurs : Maria Björkqvist [Suède] ; Blair R. Leavitt [Canada] ; Jörgen E. Nielsen [Danemark] ; Bernhard Landwehrmeyer [Allemagne] ; Daniel Ecker [Allemagne] ; Hindrik Mulder [Suède] ; Patrik Brundin [Suède] ; Sa Petersén [Suède]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-10-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Amfetamine, Anxiety, Anxiety (physiopathology), Biological Markers (cerebrospinal fluid), Brain (physiopathology), CART, CSF, Cerebrospinal fluid, Cocaine, Cross-Sectional Studies, Disease Progression, Energy Metabolism (physiology), Female, Humans, Huntington Disease (diagnosis), Huntington Disease (physiopathology), Huntington disease, Hypothalamus, Male, Middle Aged, Nerve Tissue Proteins (cerebrospinal fluid), Nervous system diseases, Neurotransmitter Agents (cerebrospinal fluid), Radioimmunoassay, Reference Values, Weight Loss (physiology), anxiety, biomarker, hypothalamus.
- MESH :
- chemical , cerebrospinal fluid : Biological Markers, Nerve Tissue Proteins, Neurotransmitter Agents.
- diagnosis : Huntington Disease.
- physiology : Energy Metabolism, Weight Loss.
- physiopathology : Anxiety, Brain, Huntington Disease.
- Cross-Sectional Studies, Disease Progression, Female, Humans, Male, Middle Aged, Radioimmunoassay, Reference Values.
Abstract
Weight loss and anxiety frequently occur in individuals with Huntington's disease (HD) but the underlying mechanisms are not well‐understood. Peptides produced in the hypothalamus are involved in regulating energy homeostasis and emotion. Recent data suggest that changes in neuropeptide levels may be reflected in the cerebrospinal fluid (CSF), and could therefore serve as biomarkers for HD. Cocaine‐ and amphetamine‐regulated transcript (CART) is a neuropetide expressed in several brain regions such as the hypothalamus, amygdala, and hippocampus. CART has been shown to increase anxiety and reduce food intake in rodents by as yet unknown mechanisms. Individuals with a CART mutation exhibit increased anxiety. In cross‐sectional CSF samples from HD patients (n = 39), we found that levels of CART peptide were significantly increased by 23% compared to control subjects (n = 28). Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21447
Affiliations:
- Allemagne, Canada, Danemark, Suède
- Bade-Wurtemberg, District de Tübingen, Hovedstaden
- Copenhague, Ulm
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Le document en format XML
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Leavitt</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Child and Family Research Institute, BC Children′s Hospital, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Nielsen, Jorgen E" sort="Nielsen, Jorgen E" uniqKey="Nielsen J" first="Jörgen E." last="Nielsen">Jörgen E. Nielsen</name><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medical Genetics, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Memory Disorders Research Unit, Department of Neurology, Rikshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Ecker, Daniel" sort="Ecker, Daniel" uniqKey="Ecker D" first="Daniel" last="Ecker">Daniel Ecker</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Mulder, Hindrik" sort="Mulder, Hindrik" uniqKey="Mulder H" first="Hindrik" last="Mulder">Hindrik Mulder</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Molecular Metabolism, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, Sa" sort="Petersen, Sa" uniqKey="Petersen " first=" Sa" last="Petersén"> Sa Petersén</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-10-15">2007-10-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1952">1952</biblScope><biblScope unit="page" to="1954">1954</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D17B2CC2F9058AADD98F86CB723D56693D56E705</idno><idno type="DOI">10.1002/mds.21447</idno><idno type="ArticleID">MDS21447</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amfetamine</term><term>Anxiety</term><term>Anxiety (physiopathology)</term><term>Biological Markers (cerebrospinal fluid)</term><term>Brain (physiopathology)</term><term>CART</term><term>CSF</term><term>Cerebrospinal fluid</term><term>Cocaine</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Energy Metabolism (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (physiopathology)</term><term>Huntington disease</term><term>Hypothalamus</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (cerebrospinal fluid)</term><term>Nervous system diseases</term><term>Neurotransmitter Agents (cerebrospinal fluid)</term><term>Radioimmunoassay</term><term>Reference Values</term><term>Weight Loss (physiology)</term><term>anxiety</term><term>biomarker</term><term>hypothalamus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Biological Markers</term><term>Nerve Tissue Proteins</term><term>Neurotransmitter Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Energy Metabolism</term><term>Weight Loss</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anxiety</term><term>Brain</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Radioimmunoassay</term><term>Reference Values</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Amfétamine</term><term>Angoisse anxiété</term><term>Chorée de Huntington</term><term>Cocaïne</term><term>Hypothalamus</term><term>Liquide céphalorachidien</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Weight loss and anxiety frequently occur in individuals with Huntington's disease (HD) but the underlying mechanisms are not well‐understood. Peptides produced in the hypothalamus are involved in regulating energy homeostasis and emotion. Recent data suggest that changes in neuropeptide levels may be reflected in the cerebrospinal fluid (CSF), and could therefore serve as biomarkers for HD. Cocaine‐ and amphetamine‐regulated transcript (CART) is a neuropetide expressed in several brain regions such as the hypothalamus, amygdala, and hippocampus. CART has been shown to increase anxiety and reduce food intake in rodents by as yet unknown mechanisms. Individuals with a CART mutation exhibit increased anxiety. In cross‐sectional CSF samples from HD patients (n = 39), we found that levels of CART peptide were significantly increased by 23% compared to control subjects (n = 28). Increased CART levels in HD therefore hold promise as a biomarker as well as a potential pathogenic mediator of symptoms. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Danemark</li><li>Suède</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Hovedstaden</li></region><settlement><li>Copenhague</li><li>Ulm</li></settlement></list><tree><country name="Suède"><noRegion><name sortKey="Bjorkqvist, Maria" sort="Bjorkqvist, Maria" uniqKey="Bjorkqvist M" first="Maria" last="Björkqvist">Maria Björkqvist</name></noRegion><name sortKey="Bjorkqvist, Maria" sort="Bjorkqvist, Maria" uniqKey="Bjorkqvist M" first="Maria" last="Björkqvist">Maria Björkqvist</name><name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name><name sortKey="Mulder, Hindrik" sort="Mulder, Hindrik" uniqKey="Mulder H" first="Hindrik" last="Mulder">Hindrik Mulder</name><name sortKey="Petersen, Sa" sort="Petersen, Sa" uniqKey="Petersen " first=" Sa" last="Petersén"> Sa Petersén</name></country><country name="Canada"><noRegion><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name></noRegion><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Nielsen, Jorgen E" sort="Nielsen, Jorgen E" uniqKey="Nielsen J" first="Jörgen E." last="Nielsen">Jörgen E. Nielsen</name></region><name sortKey="Nielsen, Jorgen E" sort="Nielsen, Jorgen E" uniqKey="Nielsen J" first="Jörgen E." last="Nielsen">Jörgen E. Nielsen</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name></region><name sortKey="Ecker, Daniel" sort="Ecker, Daniel" uniqKey="Ecker D" first="Daniel" last="Ecker">Daniel Ecker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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